Dennis Slamon George Peoples James Holland Massimo Christofanilli Trastuzumab: Mature Results in Early Breast Cancer Show Superiority REFERENCE: San Antonio Breast Cancer Symposium 2006, Abstract: 52

Dennis Slamon

George Peoples

James Holland

Massimo Christofanilli
Trastuzumab: Mature Results in Early Breast Cancer Show Superiority
REFERENCE: San Antonio Breast Cancer Symposium 2006, Abstract: 52
DENNIS SLAMON, University of California, Los Angeles
Adjuvant therapy regimens containing trastuzumab have proved superior to those with cytotoxic chemotherapy agents alone, used without the new molecular therapy. Mature results from the massive BCIRG 006 phase III randomized trial looking at adjuvant doxorubicin, cyclophosphamide, docetaxel with or without trastuzumab were presented in San Antonio by Dennis Slamon, who discussed the details with Peter Goodwin.
HER2 Peptide Vaccine Prevents Breast Cancer Recurrence
REFERENCE: San Antonio Breast Cancer Symposium 2006, Abstract: 4
GEORGE PEOPLES, Brook Army Medical Center, Houston
A vaccine to prevent breast cancer has shown early success in a study reported in San Antonio. A group from Houston presented results from the first trial of vaccination against recurrent breast cancer using the E75 single peptide vaccine. George Peoples told Karen Regester how the vaccine improved progression free survival.
Virus Cause of Breast Cancers?
REFERENCE: San Antonio Breast Cancer Symposium 2006, Abstract: 6
JAMES HOLLAND, Mount Sinai School of Medicine, New York
A virus may be the cause of human breast cancer, according to James Holland, who gave the San Antonio conference his latest findings implicating human mammary tumor virus as a leading cause of breast cancer. He discussed the data with Peter Goodwin.
Lapatinib Shows Promise as Therapy For Inflammatory Breast Cancer
REFERENCE: San Antonio Breast Cancer Symposium 2006, Abstract: 1
MASSIMO CHRISTOFANILLI, MD Anderson Cancer Center, Houston
Targeted therapy may be the best way to combat aggressive inflammatory breast cancer. Massimo Christofanilli and his colleagues selected patients with HER2neu and EGFR expression for therapy with the dual targeted inhibitor, lapatinib. Benefits were apparent within the first two weeks of treatment.
To listen this episode please go to ASCO Audio Journal of Oncology in Advance Presentations.
Related Episodes

Hope S. Rugo, MD; SABCS 2025: Selective Estrogen Degrader Giredestrant Brings Clinically Meaningful Improvements in Metastatic Breast Cancer: evERA Breast Cancer Trial
Hope S. Rugo, MD, discusses the Phase III evERA Breast Cancer trial at SABCS 2025, revealing clinically meaningful improvements with giredestrant plus everolimus for ER-positive, HER2-negative metastatic breast cancer previously treated with a CDK4/6 inhibitor. Subgroup analyses show benefits regard

Thorsten Kühn MD PhD; SABCS 2025: No Need for Axillary Node Dissection When Clinically Node-Positive Breast Cancers Convert to Node-Negative After Neoadjuvant Chemotherapy
Thorsten Kühn MD PhD discusses findings from the AXSANA/EUBREAST 3(R) study at SABCS 2025. The research indicates that breast cancer patients who convert from clinically node-positive to node-negative after neoadjuvant chemotherapy do not require axillary lymph node dissection. Less invasive surgical staging procedures were found to be non-inferior in terms of three-year outcomes, irrespective of tumor type or initial stage.

Erika Hamilton MD; 2025 SABCS: Small Molecule HER2 Inhibitor Tucatinib Improves Progression Free Survival in Patients with HER2-positive Metastatic Breast Cancer: in HER2CLIMB-05 Trial
This episode features an interview with Erika Hamilton MD at the 2025 San Antonio Breast Cancer Symposium (SABCS). Dr. Hamilton discusses findings from the HER2CLIMB-05 trial, showing that adding tucatinib to trastuzumab and pertuzumab significantly improves progression-free survival in patients with HER2-positive metastatic breast cancer as first-line maintenance therapy, with no new safety signals. This small molecule HER2 inhibitor offers a promising new option.
